A novel 5T4-targeting antibody-drug conjugate H6-DM4 exhibits potent therapeutic efficacy in gastrointestinal tumor xenograft models

5T4, also named as trophoblast glycoprotein, is often upregulated in some cancer cells. Here, we demonstrated that 5T4 was highly expressed in gastric, colorectal, and pancreatic cancer, associated with significantly poor prognosis of gastrointestinal (GI) cancer patients. To search for new targetin...

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Detalhes bibliográficos
Publicado no:Am J Cancer Res
Main Authors: Wang, Ruixue, Lai, Qinhuai, Tang, Liangze, Tao, Yiran, Yao, Yuqin, Liu, Yu, Lu, Ying, Shen, Chaoyong, Lu, Ran, Fan, Chuanwen, Zhang, Ruirui, Wang, Yuxi, Yu, Lin, Yang, Tinghan, Wu, Yangping, Peng, Yujia, Wei, Xian, Fu, Yuyin, Lai, Weirong, Gou, Lantu, Yang, Jinliang
Formato: Artigo
Idioma:Inglês
Publicado em: e-Century Publishing Corporation 2018
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934552/
https://ncbi.nlm.nih.gov/pubmed/29736307
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