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Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation
Acquisition of mutations is central to evolution; however, the detrimental effects of most mutations on protein folding and stability limit protein evolvability. Molecular chaperones, which suppress aggregation and facilitate polypeptide folding, may alleviate the effects of destabilizing mutations...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5934419/ https://ncbi.nlm.nih.gov/pubmed/29725062 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04203-x |
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