Hsp90 shapes protein and RNA evolution to balance trade-offs between protein stability and aggregation

Acquisition of mutations is central to evolution; however, the detrimental effects of most mutations on protein folding and stability limit protein evolvability. Molecular chaperones, which suppress aggregation and facilitate polypeptide folding, may alleviate the effects of destabilizing mutations...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Geller, Ron, Pechmann, Sebastian, Acevedo, Ashley, Andino, Raul, Frydman, Judith
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934419/
https://ncbi.nlm.nih.gov/pubmed/29725062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04203-x
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