Comparison of methods that use whole genome data to estimate the heritability and genetic architecture of complex traits

Multiple methods have been developed to estimate narrow-sense heritability, h(2), using single nucleotide polymorphisms (SNPs) in unrelated individuals. However, a comprehensive evaluation of these methods has not yet been performed, leading to confusion and discrepancy in the literature. We present...

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Veröffentlicht in:Nat Genet
Hauptverfasser: Evans, Luke M., Tahmasbi, Rasool, Vrieze, Scott I., Abecasis, Gonçalo R., Das, Sayantan, Gazal, Steven, Bjelland, Douglas W., de Candia, Teresa R., Goddard, Michael E., Neale, Benjamin M., Yang, Jian, Visscher, Peter M., Keller, Matthew C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5934350/
https://ncbi.nlm.nih.gov/pubmed/29700474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-018-0108-x
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