Unexpected cancer-predisposition gene variants in Cowden syndrome and Bannayan-Riley-Ruvalcaba syndrome patients without underlying germline PTEN mutations

Patients with heritable cancer syndromes characterized by germline PTEN mutations (termed PTEN hamartoma tumor syndrome, PHTS) benefit from PTEN-enabled cancer risk assessment and clinical management. PTEN-wildtype patients (~50%) remain at increased risk of developing certain cancers. Existence of...

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Publicat a:PLoS Genet
Autors principals: Yehia, Lamis, Ni, Ying, Sesock, Kaitlin, Niazi, Farshad, Fletcher, Benjamin, Chen, Hannah Jin Lian, LaFramboise, Thomas, Eng, Charis
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2018
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5933810/
https://ncbi.nlm.nih.gov/pubmed/29684080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007352
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