In vitro iCLIP-based modeling uncovers how the splicing factor U2AF2 relies on regulation by cofactors

Alternative splicing generates distinct mRNA isoforms and is crucial for proteome diversity in eukaryotes. The RNA-binding protein (RBP) U2AF2 is central to splicing decisions, as it recognizes 3′ splice sites and recruits the spliceosome. We establish “in vitro iCLIP” experiments, in which recombin...

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發表在:Genome Res
Main Authors: Sutandy, F.X. Reymond, Ebersberger, Stefanie, Huang, Lu, Busch, Anke, Bach, Maximilian, Kang, Hyun-Seo, Fallmann, Jörg, Maticzka, Daniel, Backofen, Rolf, Stadler, Peter F., Zarnack, Kathi, Sattler, Michael, Legewie, Stefan, König, Julian
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2018
主題:
Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932610/
https://ncbi.nlm.nih.gov/pubmed/29643205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.229757.117
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