In-depth characterization of the cisplatin mutational signature in human cell lines and in esophageal and liver tumors

Cisplatin reacts with DNA and thereby likely generates a characteristic pattern of somatic mutations, called a mutational signature. Despite widespread use of cisplatin in cancer treatment and its role in contributing to secondary malignancies, its mutational signature has not been delineated. We hy...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Boot, Arnoud, Huang, Mi Ni, Ng, Alvin W.T., Ho, Szu-Chi, Lim, Jing Quan, Kawakami, Yoshiiku, Chayama, Kazuaki, Teh, Bin Tean, Nakagawa, Hidewaki, Rozen, Steven G.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932606/
https://ncbi.nlm.nih.gov/pubmed/29632087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.230219.117
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