Proteinase 3 Interferes With C1q-Mediated Clearance of Apoptotic Cells

Proteinase 3 (PR3) is the autoantigen in granulomatosis with polyangiitis, an autoimmune necrotizing vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCAs). Moreover, PR3 is a serine protease whose membrane expression can potentiate inflammatory diseases such as ANCA-associated va...

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Publicat a:Front Immunol
Autors principals: Tacnet-Delorme, Pascale, Gabillet, Julie, Chatfield, Simon, Thieblemont, Nathalie, Frachet, Philippe, Witko-Sarsat, Véronique
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932363/
https://ncbi.nlm.nih.gov/pubmed/29755460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00818
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