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ONC201 Targets AR and AR-V7 Signaling, Reduces PSA and Synergizes with Everolimus in Prostate Cancer

Androgen receptor (AR) signaling plays a key role in prostate cancer progression, and androgen deprivation therapy (ADT) is a mainstay clinical treatment regimen for patients with advanced disease. Unfortunately, most prostate cancers eventually become androgen-independent and resistant to ADT with...

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Bibliografische gegevens
Gepubliceerd in:Mol Cancer Res
Hoofdauteurs: Lev, Avital, Lulla, Amriti R., Ross, Brian C., Ralff, Marie D., Makhov, Peter B., Dicker, David T., El-Deiry, Wafik S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932216/
https://ncbi.nlm.nih.gov/pubmed/29588330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-17-0614
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