Progressive IgA Nephropathy Is Associated With Low Circulating Mannan-Binding Lectin–Associated Serine Protease-3 (MASP-3) and Increased Glomerular Factor H–Related Protein-5 (FHR5) Deposition

INTRODUCTION: IgA nephropathy (IgAN) is characterized by glomerular deposition of galactose-deficient IgA1 and complement proteins and leads to renal impairment. Complement deposition through the alternative and lectin activation pathways is associated with renal injury. METHODS: To elucidate the co...

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Enregistré dans:
Détails bibliographiques
Publié dans:Kidney Int Rep
Auteurs principaux: Medjeral-Thomas, Nicholas R., Troldborg, Anne, Constantinou, Nicholas, Lomax-Browne, Hannah J., Hansen, Annette G., Willicombe, Michelle, Pusey, Charles D., Cook, H. Terence, Thiel, Steffen, Pickering, Matthew C.
Format: Artigo
Langue:Inglês
Publié: Elsevier 2017
Sujets:
Clinical Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5932138/
https://ncbi.nlm.nih.gov/pubmed/29725647
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ekir.2017.11.015
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