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Dissociable influences of APOE ε4 and polygenic risk of AD dementia on amyloid and cognition

OBJECTIVE: To investigate the effects of genetic risk of Alzheimer disease (AD) dementia in the context of β-amyloid (Aβ) accumulation. METHODS: We analyzed data from 702 participants (221 clinically normal, 367 with mild cognitive impairment, and 114 with AD dementia) with genetic data and florbeta...

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Pubblicato in:Neurology
Autori principali: Ge, Tian, Sabuncu, Mert R., Smoller, Jordan W., Sperling, Reisa A., Mormino, Elizabeth C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Lippincott Williams & Wilkins 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931806/
https://ncbi.nlm.nih.gov/pubmed/29592889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000005415
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