Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease

OBJECTIVE: To examine whether β-amyloid (Aβ) and APOE ε4 status independently contribute or interact to influence longitudinal cognitive decline in clinically normal older individuals (CN). METHODS: Data from 490 CNs were aggregated across 3 observational cohort studies (Harvard Aging Brain Study, A...

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Detalhes bibliográficos
Main Authors: Mormino, Elizabeth C., Betensky, Rebecca A., Hedden, Trey, Schultz, Aaron P., Ward, Andrew, Huijbers, Willem, Rentz, Dorene M., Johnson, Keith A., Sperling, Reisa A.
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035706/
https://ncbi.nlm.nih.gov/pubmed/24748674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/WNL.0000000000000431
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