In situ proteolysis of an N-terminal His tag with thrombin improves the diffraction quality of human aldo-keto reductase 1C3 crystals

Human aldo-keto reductase 1C3 (AKR1C3) stereospecifically reduces steroids and prostaglandins and is involved in the biotransformation of xenobiotics. Its role in various cancers makes it a potential therapeutic target for the development of inhibitors. Recombinant AKR1C3 with a thrombin-cleavable N...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr F Struct Biol Commun
Main Authors: Plavša, Jovana J., Řezáčová, Pavlína, Kugler, Michael, Pachl, Petr, Brynda, Jiří, Voburka, Zdeněk, Ćelić, Anđelka, Petri, Edward T., Škerlová, Jana
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2018
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931143/
https://ncbi.nlm.nih.gov/pubmed/29717998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X18005721
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