AKR1C enzymes sustain therapy resistance in paediatric T-ALL

BACKGROUND: Despite chemotherapy intensification, a subgroup of high-risk paediatric T-cell acute lymphoblastic leukemia (T-ALL) patients still experience treatment failure. In this context, we hypothesised that therapy resistance in T-ALL might involve aldo-keto reductase 1C (AKR1C) enzymes as prev...

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Bibliographic Details
Published in:Br J Cancer
Main Authors: Bortolozzi, Roberta, Bresolin, Silvia, Rampazzo, Elena, Paganin, Maddalena, Maule, Francesca, Mariotto, Elena, Boso, Daniele, Minuzzo, Sonia, Agnusdei, Valentina, Viola, Giampietro, te Kronnie, Geertruy, Cazzaniga, Giovanni, Basso, Giuseppe, Persano, Luca
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5931104/
https://ncbi.nlm.nih.gov/pubmed/29515258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41416-018-0014-0
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