Effective Targeting of Multiple B-Cell Maturation Antigen–Expressing Hematological Malignances by Anti-B-Cell Maturation Antigen Chimeric Antigen Receptor T Cells

B-cell maturation antigen (BCMA) expression has been proposed as a marker for the identification of malignant plasma cells in patients with multiple myeloma (MM). Nearly all MM tumor cells express BCMA, while normal tissue expression is restricted to plasma cells and a subset of mature B cells. Cons...

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Veröffentlicht in:Hum Gene Ther
Hauptverfasser: Friedman, Kevin M., Garrett, Tracy E., Evans, John W., Horton, Holly M., Latimer, Howard J., Seidel, Stacie L., Horvath, Christopher J., Morgan, Richard A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2018
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930946/
https://ncbi.nlm.nih.gov/pubmed/29641319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2018.001
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