Sorafenib improves alkylating therapy by blocking induced inflammation, invasion and angiogenesis in breast cancer cells

Molecular targeted compounds are emerging as a strategy to improve classical chemotherapy. Herein, we describe that using low dose of the multikinase inhibitor sorafenib improves cyclophosphamide antitumor activity by inhibiting angiogenesis, metastasis and promoting tumor healing in MDA-MB231 xenog...

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Veröffentlicht in:Cancer Lett
Hauptverfasser: Zanotto-Filho, Alfeu, Rajamanickam, Subapriya, Loranc, Eva, Masamsetti, Pragathi, Gorthi, Aparna, Romero, July Carolina, Tonapi, Sonal, Gonçalves, Rosangela Mayer, Reddick, Robert L., Benavides, Raymond, Kuhn, John, Chen, Yidong, Bishop, Alexander J. R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5930000/
https://ncbi.nlm.nih.gov/pubmed/29608984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2018.03.037
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