The PYHIN protein p205 regulates the inflammasome by controlling Asc expression

Members of the interferon-inducible PYHIN protein family such as Absent in Melanoma-2 and Interferon Gamma Inducible Protein (IFI) 16 bind double-stranded DNA (dsDNA) and form caspase-1 activating inflammasomes, important in immunity to cytosolic bacteria, DNA viruses or Human Immunodeficiency Virus...

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Bibliografiske detaljer
Udgivet i:J Immunol
Main Authors: Ghosh, Sreya, Wallareth, Christina, Covarrubias, Sergio, Hornung, Veit, Carpenter, Susan B., Fitzgerald, Katherine A.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929989/
https://ncbi.nlm.nih.gov/pubmed/28931603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700823
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