IKKα negatively regulates ASC-dependent inflammasome activation

The inflammasomes are multiprotein complexes that activate caspase-1 in response to infections and stress, resulting in the secretion of pro-inflammatory cytokines. Here we report that IKKα is a critical negative regulator of ASC-dependent inflammasomes. IKKα controls the inflammasome at the level o...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Martin, Bradley N., Wang, Chenhui, Willette-Brown, Jami, Herjan, Tomasz, Gulen, Muhammet F., Zhou, Hao, Bulek, Katarzyna, Franchi, Luigi, Sato, Takashi, Narla, Goutham, Zhong, Xiao-Ping, Thomas, James, Klinman, Dennis, Fitzgerald, Katherine A., Karin, Michael, Nuñez, Gabriel, Dubyak, George, Hu, Yinling, Li, Xiaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298287/
https://ncbi.nlm.nih.gov/pubmed/25266676
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms5977
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