The metalloproteinase-proteoglycans ADAMTS7 and ADAMTS12 provide an innate, tendon-specific protective mechanism against heterotopic ossification

Heterotopic ossification (HO) is a significant clinical problem with incompletely resolved mechanisms. Here, the secreted metalloproteinases ADAMTS7 and ADAMTS12 are shown to comprise a unique proteoglycan class that protects against a tendency toward HO in mouse hindlimb tendons, menisci, and ligam...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Mead, Timothy J., McCulloch, Daniel R., Ho, Jason C., Du, Yaoyao, Adams, Sheila M., Birk, David E., Apte, Suneel S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928868/
https://ncbi.nlm.nih.gov/pubmed/29618652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.92941
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