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ZSCAN4 is negatively regulated by the ubiquitin-proteasome system and the E3 ubiquitin ligase RNF20

Zscan4 is an early embryonic gene cluster expressed in mouse embryonic stem and induced pluripotent stem cells where it plays critical roles in genomic stability, telomere maintenance, and pluripotency. Zscan4 expression is transient, and characterized by infrequent high expression peaks that are qu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Biochem Biophys Res Commun
Hauptverfasser: Portney, Benjamin A., Khatri, Raju, Meltzer, W. Alex, Mariano, Jennifer M., Zalzman, Michal
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928792/
https://ncbi.nlm.nih.gov/pubmed/29477841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2018.02.155
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