Inhibition of fucosylation in human invasive ductal carcinoma reduces E‐selectin ligand expression, cell proliferation, and ERK1/2 and p38 MAPK activation

Breast cancer tissue overexpresses fucosylated glycans, such as sialyl‐Lewis X/A (sLe(X) (/A)), and α‐1,3/4‐fucosyltransferases (FUTs) in relation to increased disease progression and metastasis. These glycans in tumor circulating cells mediate binding to vascular E‐selectin, initiating tumor extrav...

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Veröffentlicht in:Mol Oncol
Hauptverfasser: Carrascal, Mylène A., Silva, Mariana, Ramalho, José S., Pen, Cláudia, Martins, Manuela, Pascoal, Carlota, Amaral, Constança, Serrano, Isabel, Oliveira, Maria José, Sackstein, Robert, Videira, Paula A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2018
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928367/
https://ncbi.nlm.nih.gov/pubmed/29215790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12163
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