Thymidine catabolism promotes NADPH oxidase-derived reactive oxygen species (ROS) signalling in KB and yumoto cells

Thymidine phosphorylase (TP) is a rate-limiting enzyme in the thymidine catabolic pathway. TP is identical to platelet-derived endothelial cell growth factor and contributes to tumour angiogenesis. TP induces the generation of reactive oxygen species (ROS) and enhances the expression of oxidative st...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tabata, Sho, Yamamoto, Masatatsu, Goto, Hisatsugu, Hirayama, Akiyoshi, Ohishi, Maki, Kuramoto, Takuya, Mitsuhashi, Atsushi, Ikeda, Ryuji, Haraguchi, Misako, Kawahara, Kohichi, Shinsato, Yoshinari, Minami, Kentaro, Saijo, Atsuro, Toyoda, Yuko, Hanibuchi, Masaki, Nishioka, Yasuhiko, Sone, Saburo, Esumi, Hiroyasu, Tomita, Masaru, Soga, Tomoyoshi, Furukawa, Tatsuhiko, Akiyama, Shin-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928239/
https://ncbi.nlm.nih.gov/pubmed/29713062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25189-y
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