Native mass spectrometry combined with enzymatic dissection unravels glycoform heterogeneity of biopharmaceuticals

Robust manufacturing processes resulting in consistent glycosylation are critical for the efficacy and safety of biopharmaceuticals. Information on glycosylation can be obtained by conventional bottom–up methods but is often limited to the glycan or glycopeptide level. Here, we apply high-resolution...

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Bibliografiska uppgifter
I publikationen:Nat Commun
Huvudupphovsmän: Wohlschlager, Therese, Scheffler, Kai, Forstenlehner, Ines C., Skala, Wolfgang, Senn, Stefan, Damoc, Eugen, Holzmann, Johann, Huber, Christian G.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928108/
https://ncbi.nlm.nih.gov/pubmed/29712889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04061-7
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