Sauchinone controls hepatic cholesterol homeostasis by the negative regulation of PCSK9 transcriptional network

Whole-transcriptome analysis and western blotting of sauchinone-treated HepG2 cells demonstrated that sauchinone regulated genes relevant to cholesterol metabolism and synthesis. In particular, it was found that the expression of proprotein convertase subtilisin/kexin type 9 (PCSK9) was downregulate...

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Pubblicato in:Sci Rep
Autori principali: Chae, Hee-Sung, You, Byoung Hoon, Kim, Dong-Yeop, Lee, Hankyu, Ko, Hyuk Wan, Ko, Hyun-Jeong, Choi, Young Hee, Choi, Sun Shim, Chin, Young-Won
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928089/
https://ncbi.nlm.nih.gov/pubmed/29712938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-24935-6
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