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G-395A polymorphism in the promoter region of the KLOTHO gene associates with frailty among the oldest-old

Frailty is characterized by a decline in physiological reserve and increased vulnerability. Previous studies have shown that KLOTHO (KL) plays a protective role in several age-related diseases. We hypothesize a probable protective effect of KL on frailty in the elderly population and included a coho...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Sci Rep
Κύριοι συγγραφείς: Hao, Qiukui, Wang, Yuting, Ding, Xiang, Dong, Biao, Yang, Ming, Dong, Birong, Wei, Yuquan
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group UK 2018
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5928057/
https://ncbi.nlm.nih.gov/pubmed/29712948
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-25040-4
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