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Elucidating the Interdependence of Drug Resistance from Combinations of Mutations
HIV-1 protease is responsible for the cleavage of 12 non-homologous sites within the Gag and Gag-Pro-Pol polyproteins in the viral genome. Under the selective pressure of protease inhibition, the virus evolves mutations within (primary) and outside of (secondary) the active site allowing the proteas...
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| Publicado no: | J Chem Theory Comput |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5927819/ https://ncbi.nlm.nih.gov/pubmed/28915040 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jctc.7b00601 |
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