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All-atom molecular dynamics of the HBV capsid reveals insights into biological function and cryo-EM resolution limits

The hepatitis B virus capsid represents a promising therapeutic target. Experiments suggest the capsid must be flexible to function; however, capsid structure and dynamics have not been thoroughly characterized in the absence of icosahedral symmetry constraints. Here, all-atom molecular dynamics sim...

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Vydáno v:eLife
Hlavní autoři: Hadden, Jodi A, Perilla, Juan R, Schlicksup, Christopher John, Venkatakrishnan, Balasubramanian, Zlotnick, Adam, Schulten, Klaus
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927769/
https://ncbi.nlm.nih.gov/pubmed/29708495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.32478
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