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Substrate rigidity-dependent positive feedback regulation between YAP and ROCK2

Extracellular matrix (ECM) stiffness influences gene expression, leading to modulation of various cellular functions. While ROCK2 regulates actomyosin activity as well as cell migration and proliferation, expression of ROCK2 is increased in response to stiffening ECM. However, the mechanism underlyi...

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Podrobná bibliografie
Vydáno v:Cell Adh Migr
Hlavní autoři: Sugimoto, Wataru, Itoh, Katsuhiko, Mitsui, Yasumasa, Ebata, Takahiro, Fujita, Hideaki, Hirata, Hiroaki, Kawauchi, Keiko
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927696/
https://ncbi.nlm.nih.gov/pubmed/28686514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336918.2017.1338233
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