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Substrate rigidity-dependent positive feedback regulation between YAP and ROCK2

Extracellular matrix (ECM) stiffness influences gene expression, leading to modulation of various cellular functions. While ROCK2 regulates actomyosin activity as well as cell migration and proliferation, expression of ROCK2 is increased in response to stiffening ECM. However, the mechanism underlyi...

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Detalhes bibliográficos
Publicado no:Cell Adh Migr
Main Authors: Sugimoto, Wataru, Itoh, Katsuhiko, Mitsui, Yasumasa, Ebata, Takahiro, Fujita, Hideaki, Hirata, Hiroaki, Kawauchi, Keiko
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927696/
https://ncbi.nlm.nih.gov/pubmed/28686514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19336918.2017.1338233
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