Merkel cell carcinoma expresses the immunoregulatory ligand CD200 and induces immunosuppressive macrophages and regulatory T cells

Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer that responds to PD-1/PD-L1 immune checkpoint inhibitors. CD200 is another checkpoint modulator whose receptor is found on tumor-promoting myeloid cells, including M2 macrophages. We found high CD200 mRNA expression in MCC tumors, and...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncoimmunology
Main Authors: Gaiser, Maria Rita, Weis, Cleo-Aron, Gaiser, Timo, Jiang, Hong, Buder-Bakhaya, Kristina, Herpel, Esther, Warth, Arne, Xiao, Ying, Miao, Lingling, Brownell, Isaac
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2018
Teme:
Brief Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5927480/
https://ncbi.nlm.nih.gov/pubmed/29721394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2018.1426517
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