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Inactivation of O(6)‐Methylguanine‐DNA Methyltransferase in Human Lung Adenocarcinoma Relates to High‐grade Histology and Worse Prognosis among Smokers
To evaluate the significance of O(6)‐methylguanine‐DNA methyltransferase (MGMT) activity in the development of human lung adenocarcinoma (AC), we investigated promoter hypermethylation of the MGMTx gene by methylation‐specific PCR, and the expression of MGMT protein by immuno‐histochemistry in relat...
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| Publicado no: | Jpn J Cancer Res |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Blackwell Publishing Ltd
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5926947/ https://ncbi.nlm.nih.gov/pubmed/11856482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2002.tb01257.x |
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