An aggrecan fragment drives osteoarthritis pain through Toll-like receptor 2

Pain is the predominant symptom of osteoarthritis, but the connection between joint damage and the genesis of pain is not well understood. Loss of articular cartilage is a hallmark of osteoarthritis, and it occurs through enzymatic degradation of aggrecan by cleavage mediated by a disintegrin and me...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:JCI Insight
Prif Awduron: Miller, Rachel E., Ishihara, Shingo, Tran, Phuong B., Golub, Suzanne B., Last, Karena, Miller, Richard J., Fosang, Amanda J., Malfait, Anne-Marie
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926921/
https://ncbi.nlm.nih.gov/pubmed/29563338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.95704
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