Functional Polymorphism of the Thymidylate Synthase Gene in Colorectal Cancer Accompanied by Frequent Loss of Heterozygosity

The thymidylate synthase (TS) gene has a polymorphic repeated sequence in its 5′‐untranslated region. The repeat length is associated with TS protein expression, which suggests that we may be able to predict the efficacy of 5‐fluorouracil (S‐FU)‐based chemotherapy from a patient's TS genotype d...

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Pubblicato in:Jpn J Cancer Res
Autori principali: Kawakami, Kazuyuki, Ishida, Yoshinori, Danenberg, Kathleen D., Omura, Kenji, Watanabe, Go, Danenberg, Peter V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2002
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5926893/
https://ncbi.nlm.nih.gov/pubmed/12460463
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.2002.tb01227.x
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