Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children

BACKGROUND: Antibodies targeting Plasmodium falciparum sporozoites play a key role in human immunity to malaria. However, antibody mechanisms that neutralize sporozoites are poorly understood. This has been a major constraint in developing highly efficacious vaccines, as we lack strong correlates of...

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Vydáno v:BMC Med
Hlavní autoři: Kurtovic, Liriye, Behet, Marije C., Feng, Gaoqian, Reiling, Linda, Chelimo, Kiprotich, Dent, Arlene E., Mueller, Ivo, Kazura, James W., Sauerwein, Robert W., Fowkes, Freya J. I., Beeson, James G.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2018
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5925837/
https://ncbi.nlm.nih.gov/pubmed/29706136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12916-018-1054-2
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