DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4(+)CD25(high) FOXP3(+) Regulatory T Cells but Does Not Affect Their Suppressive Capacity

Regulatory T cells (Treg) can show plasticity whereby FOXP3 expression, the master transcription factor for Treg suppressor function, is lost and proinflammatory cytokines are produced. Optimal FOXP3 expression strongly depends on hypomethylation of the FOXP3 gene. 5-Azacytidine (Aza) and its deriva...

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Veröffentlicht in:J Immunol Res
Hauptverfasser: Landman, Sija, Cruijsen, Marjan, Urbano, Paulo C. M., Huls, Gerwin, van Erp, Piet E. J., van Rijssen, Esther, Joosten, Irma, Koenen, Hans J. P. M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Hindawi 2018
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924998/
https://ncbi.nlm.nih.gov/pubmed/29850630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/4973964
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