DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4(+)CD25(high) FOXP3(+) Regulatory T Cells but Does Not Affect Their Suppressive Capacity

Regulatory T cells (Treg) can show plasticity whereby FOXP3 expression, the master transcription factor for Treg suppressor function, is lost and proinflammatory cytokines are produced. Optimal FOXP3 expression strongly depends on hypomethylation of the FOXP3 gene. 5-Azacytidine (Aza) and its deriva...

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Detalhes bibliográficos
Publicado no:J Immunol Res
Main Authors: Landman, Sija, Cruijsen, Marjan, Urbano, Paulo C. M., Huls, Gerwin, van Erp, Piet E. J., van Rijssen, Esther, Joosten, Irma, Koenen, Hans J. P. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924998/
https://ncbi.nlm.nih.gov/pubmed/29850630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/4973964
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