DNA Methyltransferase Inhibition Promotes Th1 Polarization in Human CD4(+)CD25(high) FOXP3(+) Regulatory T Cells but Does Not Affect Their Suppressive Capacity

Regulatory T cells (Treg) can show plasticity whereby FOXP3 expression, the master transcription factor for Treg suppressor function, is lost and proinflammatory cytokines are produced. Optimal FOXP3 expression strongly depends on hypomethylation of the FOXP3 gene. 5-Azacytidine (Aza) and its deriva...

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Detaylı Bibliyografya
Yayımlandı:J Immunol Res
Asıl Yazarlar: Landman, Sija, Cruijsen, Marjan, Urbano, Paulo C. M., Huls, Gerwin, van Erp, Piet E. J., van Rijssen, Esther, Joosten, Irma, Koenen, Hans J. P. M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Hindawi 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924998/
https://ncbi.nlm.nih.gov/pubmed/29850630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2018/4973964
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