TMEM59 potentiates Wnt signaling by promoting signalosome formation

Wnt/β-catenin signaling controls development and adult tissue homeostasis by regulating cell proliferation and cell fate decisions. Wnt binding to its receptors Frizzled (FZD) and low-density lipoprotein-related 6 (LRP6) at the cell surface initiates a signaling cascade that leads to the transcripti...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Gerlach, Jan P., Jordens, Ingrid, Tauriello, Daniele V. F., van ‘t Land-Kuper, Ineke, Bugter, Jeroen M., Noordstra, Ivar, van der Kooij, Johanneke, Low, Teck Y., Pimentel-Muiños, Felipe X., Xanthakis, Despina, Fenderico, Nicola, Rabouille, Catherine, Heck, Albert J. R., Egan, David A., Maurice, Madelon M.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2018
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924918/
https://ncbi.nlm.nih.gov/pubmed/29632210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1721321115
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