Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes

Oxidative stress (OS)-induced retinal pigment epithelium (RPE) cell apoptosis is critically implicated in the pathogenesis of age-related macular degeneration (AMD), a leading cause of blindness in the elderly. Heterochromatin, a compact and transcriptional inert chromatin structure, has been recent...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Gong, Lili, Liu, Fangyuan, Xiong, Zhen, Qi, Ruili, Luo, Zhongwen, Gong, Xiaodong, Nie, Qian, Sun, Qian, Liu, Yun-Fei, Qing, Wenjie, Wang, Ling, Zhang, Lan, Tang, Xiangcheng, Huang, Shan, Li, Gen, Ouyang, Hong, Xiang, Mengqing, Nguyen, Quan Dong, Liu, Yizhi, Li, David Wan-Cheng
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
Témata:
PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924883/
https://ncbi.nlm.nih.gov/pubmed/29622681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1715237115
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