Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse

KEY POINTS: Synapses have high energy demands which increase during intense activity. We show that presynaptic terminals can utilise extracellular glucose or lactate to generate energy to maintain synaptic transmission. Reducing energy substrates induces a metabolic stress: presynaptic ATP depletion...

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Bibliografski detalji
Izdano u:J Physiol
Glavni autori: Lucas, Sarah J., Michel, Christophe B., Marra, Vincenzo, Smalley, Joshua L., Hennig, Matthias H., Graham, Bruce P., Forsythe, Ian D.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2018
Teme:
Neuroscience
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924824/
https://ncbi.nlm.nih.gov/pubmed/29430661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275107
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