Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse

KEY POINTS: Synapses have high energy demands which increase during intense activity. We show that presynaptic terminals can utilise extracellular glucose or lactate to generate energy to maintain synaptic transmission. Reducing energy substrates induces a metabolic stress: presynaptic ATP depletion...

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Publicat a:J Physiol
Autors principals: Lucas, Sarah J., Michel, Christophe B., Marra, Vincenzo, Smalley, Joshua L., Hennig, Matthias H., Graham, Bruce P., Forsythe, Ian D.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2018
Matèries:
Neuroscience
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924824/
https://ncbi.nlm.nih.gov/pubmed/29430661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275107
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