Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse

KEY POINTS: Synapses have high energy demands which increase during intense activity. We show that presynaptic terminals can utilise extracellular glucose or lactate to generate energy to maintain synaptic transmission. Reducing energy substrates induces a metabolic stress: presynaptic ATP depletion...

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Pubblicato in:J Physiol
Autori principali: Lucas, Sarah J., Michel, Christophe B., Marra, Vincenzo, Smalley, Joshua L., Hennig, Matthias H., Graham, Bruce P., Forsythe, Ian D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2018
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924824/
https://ncbi.nlm.nih.gov/pubmed/29430661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275107
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