Glucose and lactate as metabolic constraints on presynaptic transmission at an excitatory synapse

KEY POINTS: Synapses have high energy demands which increase during intense activity. We show that presynaptic terminals can utilise extracellular glucose or lactate to generate energy to maintain synaptic transmission. Reducing energy substrates induces a metabolic stress: presynaptic ATP depletion...

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Detalhes bibliográficos
Publicado no:J Physiol
Main Authors: Lucas, Sarah J., Michel, Christophe B., Marra, Vincenzo, Smalley, Joshua L., Hennig, Matthias H., Graham, Bruce P., Forsythe, Ian D.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924824/
https://ncbi.nlm.nih.gov/pubmed/29430661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP275107
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