Induction of Type I Interferons by Therapeutic Nanoparticle-Based Vaccination Is Indispensable to Reinforce Cytotoxic CD8(+) T Cell Responses During Chronic Retroviral Infection

T cell dysfunction and immunosuppression are characteristic for chronic viral infections and contribute to viral persistence. Overcoming these burdens is the goal of new therapeutic strategies to cure chronic infectious diseases. We recently described that therapeutic vaccination of chronic retrovir...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Knuschke, Torben, Rotan, Olga, Bayer, Wibke, Kollenda, Sebastian, Dickow, Julia, Sutter, Kathrin, Hansen, Wiebke, Dittmer, Ulf, Lang, Karl S., Epple, Matthias, Buer, Jan, Westendorf, Astrid M.
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924795/
https://ncbi.nlm.nih.gov/pubmed/29740425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00614
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