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Pancreatic β cells overexpressing hIAPP impaired mitophagy and unbalanced mitochondrial dynamics
Human islet amyloid polypeptide (hIAPP), or amylin, has the tendency to aggregate into insoluble amyloid fibrils, a typical feature of islets from type 2 diabetes individuals. Thus, we investigated comparatively the impact of hIAPP on key pathways involved in pancreatic beta survival. INS1E-hIAPP ce...
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| Publicado no: | Cell Death Dis |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5924657/ https://ncbi.nlm.nih.gov/pubmed/29705815 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0533-x |
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