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Distinct CD40L Receptors Mediate Inflammasome Activation and Secretion of IL-1β and MCP-1 in Cultured Human Retinal Pigment Epithelial Cells

CD40L signaling occurs in several diseases with inflammatory components, including ocular and retinal diseases. However, it has never been evaluated as a pathogenic mechanism in age-related macular degeneration (AMD) or as an inducer of inflammasome formation in any cell type. mRNA and protein level...

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Publicat a:Exp Eye Res
Autors principals: Bian, Zong-Mei, Field, Matthew G., Elner, Susan G., Kahlenberg, J. Michelle, Elner, Victor M.
Format: Artigo
Idioma:Inglês
Publicat: 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924621/
https://ncbi.nlm.nih.gov/pubmed/29454857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exer.2018.02.014
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