Photoactivatable drugs for nicotinic optopharmacology

Photoactivatable (‘caged’) pharmacological agents have revolutionized neuroscience but the palette of available compounds is limited. We describe a general method for caging tertiary amines using a stable quaternary ammonium linkage that elicits a red-shift in activation wavelength. We prepared a ph...

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Publicado no:Nat Methods
Main Authors: Banala, Sambashiva, Arvin, Matthew C., Bannon, Nicolas M., Jin, Xiao-Tao, Macklin, John J., Wang, Yong, Peng, Can, Zhao, Guiqing, Marshall, John J., Gee, Kyle R., Wokosin, David L., Kim, Veronica J., McIntosh, J. Michael, Contractor, Anis, Lester, Henry A., Kozorovitskiy, Yevgenia, Drenan, Ryan M., Lavis, Luke D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923430/
https://ncbi.nlm.nih.gov/pubmed/29578537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.4637
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