Holotoxin A(1) Induces Apoptosis by Activating Acid Sphingomyelinase and Neutral Sphingomyelinase in K562 and Human Primary Leukemia Cells

Marine triterpene glycosides are attractive candidates for the development of anticancer agents. Holotoxin A(1) is a triterpene glycoside found in the edible sea cucumber, Apostichopus (Stichopus) japonicus. We previously showed that cladoloside C(2), the 25(26)-dihydro derivative of holotoxin A(1),...

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Gepubliceerd in:Mar Drugs
Hoofdauteurs: Yun, Seong-Hoon, Sim, Eun-Hye, Han, Sang-Heum, Han, Jin-Yeong, Kim, Sung-Hyun, Silchenko, Alexandra S., Stonik, Valentin A., Park, Joo-In
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2018
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923410/
https://ncbi.nlm.nih.gov/pubmed/29642569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md16040123
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