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Holotoxin A(1) Induces Apoptosis by Activating Acid Sphingomyelinase and Neutral Sphingomyelinase in K562 and Human Primary Leukemia Cells

Marine triterpene glycosides are attractive candidates for the development of anticancer agents. Holotoxin A(1) is a triterpene glycoside found in the edible sea cucumber, Apostichopus (Stichopus) japonicus. We previously showed that cladoloside C(2), the 25(26)-dihydro derivative of holotoxin A(1),...

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Dades bibliogràfiques
Publicat a:Mar Drugs
Autors principals: Yun, Seong-Hoon, Sim, Eun-Hye, Han, Sang-Heum, Han, Jin-Yeong, Kim, Sung-Hyun, Silchenko, Alexandra S., Stonik, Valentin A., Park, Joo-In
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923410/
https://ncbi.nlm.nih.gov/pubmed/29642569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/md16040123
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