Treatment with Atorvastatin Provides Additional Benefits to Imipenem in a Model of Gram-Negative Pneumonia Induced by Klebsiella pneumoniae in Mice

The clinical pathogen Klebsiella pneumoniae is a relevant cause of nosocomial infections, and resistance to current treatment with carbapenem antibiotics is becoming a significant problem. Statins are inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) used for controlling plasma cholester...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: de Paula, Talles Prosperi, Santos, Patrícia Campi, Arifa, Raquel Duque do Nascimento, Vieira, Angélica T., Baltazar, Ludmila de Matos, Ávila, Thiago Vinícius, Fagundes, Caio Tavares, Garcia, Zélia Menezes, Lima, Renata Lacerda, Teixeira, Mauro Martins, Souza, Danielle G.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2018
Sujets:
Experimental Therapeutics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5923152/
https://ncbi.nlm.nih.gov/pubmed/29463546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00764-17
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