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Virulent Poxviruses Inhibit DNA Sensing by Preventing STING Activation
Cytosolic recognition of DNA has emerged as a critical cellular mechanism of host immune activation upon pathogen invasion. The central cytosolic DNA sensor cGAS activates STING, which is phosphorylated, dimerizes and translocates from the endoplasmic reticulum (ER) to a perinuclear region to mediat...
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| Publicado no: | J Virol |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5923072/ https://ncbi.nlm.nih.gov/pubmed/29491158 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02145-17 |
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