Hypoexcitability precedes denervation in the large fast-contracting motor units in two unrelated mouse models of ALS

Hyperexcitability has been suggested to contribute to motoneuron degeneration in amyotrophic lateral sclerosis (ALS). If this is so, and given that the physiological type of a motor unit determines the relative susceptibility of its motoneuron in ALS, then one would expect the most vulnerable motone...

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Bibliografske podrobnosti
izdano v:eLife
Main Authors: Martínez-Silva, María de Lourdes, Imhoff-Manuel, Rebecca D, Sharma, Aarti, Heckman, CJ, Shneider, Neil A, Roselli, Francesco, Zytnicki, Daniel, Manuel, Marin
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2018
Teme:
Neuroscience
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5922970/
https://ncbi.nlm.nih.gov/pubmed/29580378
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.30955
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