SMAD4 and NF1 mutations as potential biomarkers for poor prognosis to cetuximab-based therapy in Chinese metastatic colorectal cancer patients

BACKGROUND: Cetuximab, an anti-EGFR monoclonal antibody, is used in combination with chemotherapy in clinic to enhance the outcome in metastatic colorectal cancer (mCRC) patients with only ~ 20% response rate. To date only activating mutations in KRAS and NRAS have been identified as poor prognosis...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Mei, Zhu, Shao, Yang W., Lin, Peinan, Cai, Xiaomin, Wang, Biao, Ding, Yan, Ma, Xiangyuan, Wu, Xue, Xia, Yewei, Zhu, Dongqin, Shu, Yongqian, Fu, Zan, Gu, Yanhong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921972/
https://ncbi.nlm.nih.gov/pubmed/29703253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-018-4298-5
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados