Decreased Levels of Active SMAD2 Correlate with Poor Prognosis in Gastric Cancer

BACKGROUND: TGF-β plays a dual role in the progression of human cancer. During the early stages of carcinogenesis, TGF-β functions as a tumor suppressor. During the late stages of tumor development, however, TGF-β can promote tumor growth and metastasis. A shift in Smad2/3 phosphorylation from the c...

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Autori principali: Wu, Yijun, Li, Qi, Zhou, Xinhui, Yu, Jiren, Mu, Yunchuan, Munker, Stefan, Xu, Chengfu, Shen, Zhe, Müllenbach, Roman, Liu, Yan, Li, Li, Gretz, Norbert, Zieker, Derek, Li, Jun, Matsuzaki, Kouichi, Li, Youming, Dooley, Steven, Weng, Honglei
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3334357/
https://ncbi.nlm.nih.gov/pubmed/22539990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0035684
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