Cytochrome P450 epoxygenase-derived epoxyeicosatrienoic acids contribute to insulin sensitivity in mice and in humans

AIMS/HYPOTHESIS: Insulin resistance is frequently associated with hypertension and type 2 diabetes. The cytochrome P450 (CYP) arachidonic acid epoxygenases (CYP2C, CYP2J) and their epoxyeicosatrienoic acid (EET) products lower blood pressure and may also improve glucose homeostasis. However, the dir...

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Veröffentlicht in:Diabetologia
Hauptverfasser: Gangadhariah, Mahesha H., Dieckmann, Blake W., Lantier, Louise, Kang, Li, Wasserman, David H., Chiusa, Manuel, Caskey, Charles F., Dickerson, Jaime, Luo, Pengcheng, Gamboa, Jorge L., Capdevila, Jorge H., Imig, John D., Yu, Chang, Pozzi, Ambra, Luther, James M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921930/
https://ncbi.nlm.nih.gov/pubmed/28352940
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-017-4260-0
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