A High Prevalence of Functional Inactivation by Methylation Modification of p16(INK4A)/CDKN2/MTS1 Gene in Primary Urothelial Cancers

We analyzed the genetic and epigenetic alterations p16(INK4A)/CDKN2/MTSl gene (MTS1 gene) in 38 primary urothelial cancers. Genetic alterations of the MTS1 gene consisted of one base substitution mutation in exon 2(2.6%)and 6 homozygous deletions (16.2%). Hypermethylation of the 5’CpG island in exon...

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Publicado en:Jpn J Cancer Res
Main Authors: Akao, Toshiya, Kakehi, Yoshiyuki, Itoh, Noriyuki, Özdemir, Enver, Shimizu, Takashi, Tachibana, Akira, Sasaki, Masao S., Yoshida, Osamu
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Publishing Ltd 1997
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5921315/
https://ncbi.nlm.nih.gov/pubmed/9439683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1349-7006.1997.tb00332.x
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